Design revolution in the production of iontophoresis pipettes

Based on the design requests of Prof. Thiele, Hilgenberg GmbH developed different models of new capillary profiles, which serve for the production of iontophoresis pipettes.

Iontophoresis electrodes consist traditionally of a central fluid filled recording channel and various flanking channels for the drug delivery. These are used for the observation of local neuronal activity in the brain and its dependence on different brain chemicals/pharmaceuticals. The traditional design lacked mechanical stability and thus either required the use of guide tubes (which are inserted to variable depth into the brain tissue) or the opening of the dura. Both of these manipulations affect the integrity of the neural tissue and are therefore best avoided.

 

The new capillary profiles of Hilgenberg have a central glass capillary, in which a tungsten-electrode is sealed and two (or four) flanking capillaries, which are used as channels for the delivery of the drugs/pharmaceuticals of interest to the neuronal tissue. The design is so small that the surrounding tissue is not damaged, but it is sturdy enough to pass through the duramater (the connective tissue surrounding the brain) without needing a guide tube. The capillaries have a filament structure, which enables a blister-free filling of the channels with an appropriate conductive liquid.

 

The new profiles allow the group, headed by Prof. Thiele, the manufacturing of very thin tungsten-in –glass electrodes with flanking pipettes. In comparison with classic iontophoresis pipettes, the end product, based on the new Hilgenberg pipettes, has a much better mechanical stability, excellent electrical recording properties and allow for the highly accurate application of the pharmaceuticals of interest.

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  • Glass tube with side-opening
  • Glass fibers with sphere formed end
  • NMR Tubes with thread for low vacuum applications
  • Mark tubes with special inner surface
  • Mini test tubes with extended flange
  • New preform for redrawing of capillaries
  • Test tubes with sagging at the bottom
  • Cloning cylinders with numbering
  • Large-volume theta cross-section capillaries
  • High tightness with new standard cap
  • Complex component made of quartz glass
  • Dropper pipettes in many sizes and designs
  • Packing glasses protected from light
  • Ampoules with built-in test leckage
  • Thick-walled sample vessels
  • Measuring ampoules with conical bottom
  • Special glass capillaries for measurements
  • Glass capillaries with constriction
  • Finely scaled glass cannulas
  • CNC processing of glass plates
  • New 5 mm NMR standard caps
  • Glass crucible for thermal analyses
  • Glass capillaries with graduation
  • Square capillary with 9 internal channels
  • 9-fold capillary made of borosilicate glass 3.3
  • Our tool for cutting glass capillaries
  • Diamond wire for cutting capillaries
  • Sight glasses (laser structured)
  • Very thick-walled capillaries
  • Polyimide coated filling needles
  • Ampoules with small volume
  • NMR tubes colored (UV protection)
  • NMR septum caps (increased denseness)
  • NMR tubes (barcode & constriction)
  • Mark tubes with perforated bottom
  • Test tubes with hole e.g. as vent
  • Test tubes with grooved rim
  • Oval capillaires (thin-walled)
  • Triangular capillaries (thin-walled)
  • Twisted capillaries by hot forming
  • Multi-channel capillaries (circular array)
  • Special light pipe made of glass
  • Luggin-capillary for measurements
  • Test mandrels (different materials)
  • Carpoules with special-rolled rim
  • Glass capillary for the stimulation
  • XRD-capillary with Luer-connector
  • Glass nozzle with seal-and retaining ring
  • Glass capillary with side-mounted connectors
  • Easily destructible glass ampoules
  • Glass rods with surface patterning
  • Long-conical focusing nozzles
  • Surface patterning of glass substrates
  • Laser sublimation-drilling in flat capillaries
  • Thin needles up to 180 ° flexible
  • Glass needles with curved tip
  • Polished to precision glass rings
  • Glass rods with partially-frosted surface
  • Sealing glass with high thermal expansion